Nonproducing state of Rous sarcoma cells: its contagiousness in chicken cell cultures.
نویسنده
چکیده
Nonproducing Rous sarcoma cells of the chicken were capable of transmitting the Rous sarcoma virus genome to neighboring chick embryo fibroblasts. This transfer required close proximity of sarcoma and normal cells and may have been mediated by a subcellular infectious agent which was found to be released from nonproducing cells.
منابع مشابه
Chromatographic analyses of isoaccepting tRNAs from avian tumor viruses.
Low-molecular-weight RNA from transforming viruses (Rous sarcoma virus-Rous-associated virus 1, Schmidt-Ruppin strain of Rous sarcoma virus, and sarcoma-B(77)), from nontransforming viruses (Rous-associated virus 1 and sarcoma-NTB(77)), and from chicken liver, chicken embryo fibroblast, and Rous sarcoma virus-Rous-associated virus 1-transformed chicken embryo fibroblast was isolated and purifie...
متن کاملRubin H. A virus in chick embryos which induces resistance in vitro to infection with Rous sarcoma virus. Proc. Nat. Acad. Sci. US 46:1105-19. 1960
Occasional cell cultures made from chicken embryos were resistant to infection with Rous sarcoma virus (RSV). A virus was isolated from the medium of these cultures that caused sensitive cultures to become resistant. This virus belonged to the avian lymphomatosis group. Other viruses of the group also induced resistance to infection by RSV. Thisprovided the first assay in vitro for leukemia vir...
متن کاملTransformation-sensitive isoactin in passaged chick embryo fibroblasts transformed by Rous sarcoma virus
Transformation by Rous sarcoma virus (RSV) has been reported to block the expression of differentiated cell products in chicken cells. The expression of these proteins may or may not be suppressed when temperature-sensitive mutants are shifted from the nonpermissive to the permissive temperature. A general characteristic of cellular transformation is the disruption of the microfilament system. ...
متن کاملThe age of the tumor-bearing hosts as a factor conditioning the transmissibility of the Rous sarcoma by filtrates and cells.
Fundamentally, the present paper is concerned with both the state of the Rous sarcoma virus— masked or free—when the tumor is made to grow either in old or in young hosts, as well as with properties of the tumor itself, associated with the virus in either state. It is well known that the causative viruses of chicken sarcoma can vanish in the most unpre dictable way, so that filtrates from a...
متن کاملThe early history of tumor virology: Rous, RIF, and RAV.
One hundred years ago Peyton Rous recovered a virus, now known as the Rous sarcoma virus (RSV), from a chicken sarcoma, which reproduced all aspects of the tumor on injection into closely related chickens. There followed recovery of causal viruses of tumors of different morphology from 4 more of 60 chicken tumors. Subsequent studies in chickens of the biology of the first RSV isolated moved slo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of virology
دوره 1 4 شماره
صفحات -
تاریخ انتشار 1967